SOPHiA DDM

Genomic analysis platform that calls, annotates and pre-classifies variants from sequencing data for clinical teams.

At a glance

Type: Clinician platform
Platforms: Web · API
Who it’s for: Clinicians, health systems and researchers
Where it’s available: 4 markets
Sources cited: 2
In the library since: 16 September 2026

What it does

SOPHiA DDM takes raw next-generation sequencing output and returns a shortlist of variants with annotation and a preliminary classification, so a clinical or laboratory team is reviewing candidates rather than raw signal.

Read the full description

Pre-classification is the interesting and contentious part. Ordering the list is what makes it usable; it also decides what a reviewer sees first, and therefore what they are most likely to act on. A tool of this kind shapes the report even when it does not write it.

It is used across oncology, hereditary cancer, rare disease and metabolic testing, and the company states it is IVDR-certified.

Patterns this product illustrates

Patterns

AIHigh clinical risk

Human review of AI output before it enters the record

An AI-drafted output (a clinical note, a radiology pre-read, a variant classification) is presented to a named clinician as a draft, with the means to check it against its source, before anything is filed, signed or acted on. The pattern is the review step itself: what is shown, what can be verified, and what the clinician has to do to accept it.

3 products